Last edited by Tygolmaran
Tuesday, July 21, 2020 | History

5 edition of Telomeres and telomerase found in the catalog.

Telomeres and telomerase

methods and protocols

by Zhou Songyang

  • 119 Want to read
  • 30 Currently reading

Published by Humana/Springer in Totowa, N.J .
Written in English

    Subjects:
  • Telomerase,
  • Laboratory manuals,
  • Physiology,
  • Telomere

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by Zhou Songyang
    SeriesMethods in molecular biology -- 735, Springer protocols, Springer protocols, Methods in molecular biology (Clifton, N.J.) -- v. 735.
    Classifications
    LC ClassificationsQP606.T44 T45 2011
    The Physical Object
    Paginationx, 191 p. :
    Number of Pages191
    ID Numbers
    Open LibraryOL25071663M
    ISBN 101617790915
    ISBN 109781617790911
    LC Control Number2011924473
    OCLC/WorldCa706784499

    As I was actually writing this article, one of the most significant studies to be published pertaining to telomeres in recent years came out of Maria Basco’s lab from Spain. I will discuss it more at length below. It shows just how important it is to orchestrate telomere length and telomerase. item 3 Telomeres and Telomerase in Cancer by Keiko Hiyama (English) Paperback Book Free 3 - Telomeres and Telomerase in Cancer by Keiko Hiyama (English) Paperback Book .

    1 Telomeres and Telomerase in Humans 13 the function of important organs, such as the bone marrow, intestine, skin, etc. However, when th ese cells stop divi ding and/or ar e differenti ated. Owing to the significant role of telomere and telomerase in tumor immortalization understanding their amassed influence on cancer is crucial for cancer therapy. In this context, this book chapter is focused on disseminating the integrated impact of telomere and telomerase on cancer : Angayarkanni Jayaraman, Kalarikkal Gopikrishnan Kiran, Palaniswamy Muthusamy.

      Telomeres sit at the end of strands of DNA, like the protective caps on shoelaces. Stress from a rough lifestyle will shorten those caps, making it more likely that cells will stop dividing and essentially die. Too many of these senescent cells accelerates human aging, the pair say.   And they do so without any further shortening of their telomeres. This remarkable demonstration (reported by Bodnar et. al. in the 16 January issue of Science) provides the most compelling evidence yet that telomerase and maintenance of telomere length .


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Telomeres and telomerase by Zhou Songyang Download PDF EPUB FB2

The New York Times bestselling book coauthored by the Nobel Prize winner who discovered telomerase and telomeres' role in the aging process and the health psychologist who has done original research into how specific lifestyle and psychological habits can protect telomeres, slowing disease and improving life/5().

Twenty-five years after the disclosure of the telomeric DNA sequence and 22 years after the discovery of telomerase, it has become clear that telomeres and telomerase influence disease of human ageing including cancer. This book summarizes our current knowledge on the role of telomeres and.

Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.5/5(2).

Cutting-edge and thorough, Telomeres and Telomerase: Methods and Protocols, Third Edition is a valuable and informative resource for anyone who is interested in the developing field of telomeres and telomerase.

The New York Times bestselling book coauthored by the Nobel Prize winner who discovered telomerase and telomeres' role in the aging process and the health psychologist who has done original research into how specific lifestyle and psychological habits can protect telomeres, slowing disease and improving life/5.

"The Telomerase Revolution" describes the current theories of what causes aging, debunks several myths and describes the role of telomeres in most aging-related diseases. Although at times the book uses more medical and scientific jargon than is palatable in a book aimed at a lay audience, the basic arguments and facts * I received a free copy of this book from NetGalley in 4/5.

A New Way to Think of Aging and Health. Synopsis: This fresh, fascinating and often funny book by Dr. Ed Park teaches you why we get old and sick and describes the journeys back to health and youth experienced after taking Telomerase Activation Medicine. It outlines a future in which Telomerase Activation Medicine has changed all your expectations about getting old.

Telomeres are the protective DNA-protein complexes found at the ends of eukaryotic chromosomes. Telomeric DNA consists of tandem repeats of a simple, often G-rich, sequence specified by the action of telomerase, and complete replication of telomeric DNA requires telomerase. Telomerase is a specialized cellular ribonucleoprotein reverse by: Infoaging Guide to Telomeres and Telomerase | 3.

factor limiting cell division. While. some have likened this to a genetic biological clock, others have described the telomere as a fuse that becomes shorter and shorter, until it sets off a kind of cellular time bomb that wreaks havoc on the cell’s internal work-ings. Today, researchers continueFile Size: KB.

Telomerase is a cellular reverse transcriptase (molecular motor) that adds new DNA onto the telomeres that are located at the ends of chromosomes (1, 15–17).While the importance of telomeres has been recognized for a long time (18–19), the DNA sequence of telomeres was somewhat more recent (20–21).Telomeres in mammals consist of long tracts of the hexameric TTAGGG nucleotide repeat Cited by: Telomeres as protective "caps" on the tips of eukaryotic chromosomes.

How telomerase extends telomeres. If you're seeing this message, it means we're having trouble loading external resources on. Features: An introduction to telomeres and telomerase begins the book. The 17 chapters provide different assays to study telomere proteins and the responses of telomere DNA, including detailed examinations of the biochemical, molecular and proteomic approaches in the understanding of telomere : Zhou Songyang.

There are also antioxidants in beans, nuts, seeds, whole grains, and green tea. In a study in China, adults who drank 3 cups of green tea a day had.

telomerase: an enzyme in eukaryotic cells that adds a specific sequence of DNA to the telomeres of chromosomes after they divide, giving the chromosomes stability over time. The End Problem of Linear DNA Replication. Linear chromosomes have an end problem. After DNA replication, each newly synthesized DNA strand is shorter at its 5′ end than.

This book is authored by Dr. Elizabeth Blackburn, a molecular biologist, who in won the Nobel Prize in Medicine for her discovery of telomeres and the key enzyme associated with their.

We all have health spans – the number of years we remain healthy, active and disease-free – and the shortening of our telomeres contributes to ageing and our entry from health span into disease span. But we can [do things that] affect our telomerase and telomeres, that can [delay] entry from health span to disease : Zoë Corbyn.

A Liz Blackburn, who co-wrote the book with me, made seminal discoveries about telomere length and telomerase around thirty years ago, in single-celled organisms. When telomerase was high, the organism became immortalized, and lived on and on.

When telomerase was blocked, the telomeres shortened, and the organism died. The story of molecular biologist Elizabeth Blackburn and her groundbreaking research on telomeres and what it reveals about the resourceful opportunism that characterizes the best scientific thinking.

Molecular biologist Elizabeth Blackburn—one of Time magazine's “Most Influential People in the World” in —made headlines in when she was dismissed from the President's.

The chapters in this book discuss genetic, proteomic, genomic, biochemical, and molecular approaches that provide insight into the complex protein interaction networks active in the telomere chromatin. This book also details information regarding telomere dynamics in response to stress or stimuli.

Broad-ranging and highly practical, Telomeres and Telomerase: Methods and Protocols provides molecular and cell biologists, cancer researchers, and cellular pathologists with the core array of productive techniques needed today to develop telomerase inhibitors and clinically valuable diagnostic/prognostic telomerase markers.

Telomerase also acts to prevent chromosome fusions. The net elongation of the bulk of the telomeres in a cell by telomerase can be uncoupled from its ability to protect from chromosome fusions, in yeast and human cells, (see Fig.

1).Cited by: The discovery of telomerase expression in a majority of tumors and the recognition of its potential role in the aging process has dramatically raised its profile as a target for therapeutic intervention.

In Telomeres and Telomerase: Methods and Prools, John A. Double and Michael J. Thompson Price: $Telomeres are nucleoprotein structures located at the ends of linear chromosomes. In most human adult normal somatic cells, telomeres shorten after each cellular division.

This shortening ultimately leads to senescence and/or apoptosis. By contrast, in most cancer cells, telomerase activation compensates this loss and confers to these cells their infinite cell proliferation : Joëlle El Hajj, Delphine Garsuault, Claire Bouyer, Eric Nguyen, George Hilal, Evelyne Ségal-Bendirdj.